(GLENDALE, AZ) - Peyton Manning threw for 379 yards and four touchdowns to lead the Indianapolis Colts to an impressive 31-10 road victory over the Arizona Cardinals.
Reggie Wayne was manning's favorite target, catching seven passes for 126 yards, including a circus catch that resulted in a 20-yard touchdown.
Manning out-dueled fellow Super Bowl MVP Kurt Warner with plenty of help from a Colts defense that spent more than 45 minutes on the field in last Monday night's win in Miami.
Warner was sacked four times - twice by Dwight Freeney and harassed throughout the evening.
Despite the pressure, Warner completed 30 of 52 passes for 332 yards and a touchdown, but he did throw a pair of interceptions.
The Colts improve to 3 and 0 while the Cardinals fall to 1 and 2.
Indianapolis returns home to face the Seattle Seahawks on Sunday.
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